• CBI

Coronavirus Protein Microarray

Coronavirus Protein Microarray



Comparison of different lab-tests





Technical advances


  • Multiplexed. Simultaneously detect serum IgG/IgM and profile the immune responses against many coronaviral proteins. 

  • Accurate. Since we compare many proteins from SARS-CoV-2, SARS-CoV, and MERS-CoV, the false negative or non-specific bindings can be evaluated. Also, the combination of multiple markers always can help the specificity and accuracy for the diagnosis.

  • Flexible. We can include the protein with common mutations that observed in the clinical samples and provide a deeper view of the impact of SARS-CoV-2 mutations. For the clinical applications, it is also flexible to discover and combine different markers for the diagnosis, prognosis, and severity classifications.

  • Sensitive. Only need 1 microliter serum the assay which is less than a drop of blood. In a microliter, we can acquire numerous data information for the research, clinical, and epidemical uses.

  • Specific. The protein microarray is a useful platform to show the specificity of the biologicals. The coronavirus protein array will speed up the process of developing biologicals for both detection and medical use.

Results


  • Highly sensitive. Can detect 50ng antibodies which is 1000x lower than ELISA method.

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  • Test 33 COVID-19 positive serum and 32 positive (sensitivity rate 97.0%)

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  • Test 35 control serum and 34 negative (specificity rate 97.1%)

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